[HTML][HTML] Nox4 NADPH oxidase mediates peroxynitrite-dependent uncoupling of endothelial nitric-oxide synthase and fibronectin expression in response to …

DY Lee, F Wauquier, AA Eid, LJ Roman… - Journal of Biological …, 2013 - ASBMB
Background: Oxidative stress is critical for the fibrotic response of mesangial cells (MCs) to
angiotensin II. Results: Nox4-and mitochondrial reactive oxygen species (ROS)-dependent
endothelial nitric-oxide synthase (eNOS) uncoupling led to fibronectin accumulation in MCs
stimulated by angiotensin II. Conclusion: The Nox4/mitochondrial ROS/eNOS pathway
mediates angiotensin II-induced MC injury. Significance: Targeting Nox4 and mitochondrial
ROS is a promising therapeutic approach. Activation of glomerular mesangial cells (MCs) by …