[HTML][HTML] Glyceraldehyde-3-phosphate dehydrogenase is activated by lysine 254 acetylation in response to glucose signal
The altered metabolism in most tumor cells consists of elevated glucose uptake and
increased glycolysis even in the presence of high oxygen tension. Glyceraldehyde-3-
phosphate dehydrogenase (GAPDH) is an obligatory enzyme in glycolysis. Here, we report
that acetylation at lysine 254 (K254) increases GAPDH activity in response to glucose.
Furthermore, acetylation of GAPDH (K254) is reversibly regulated by the acetyltransferase
PCAF and the deacetylase HDAC5. Substitution of K254 to glutamine compromises the …
increased glycolysis even in the presence of high oxygen tension. Glyceraldehyde-3-
phosphate dehydrogenase (GAPDH) is an obligatory enzyme in glycolysis. Here, we report
that acetylation at lysine 254 (K254) increases GAPDH activity in response to glucose.
Furthermore, acetylation of GAPDH (K254) is reversibly regulated by the acetyltransferase
PCAF and the deacetylase HDAC5. Substitution of K254 to glutamine compromises the …