AML evolution from preleukemia to leukemia and relapse
LI Shlush, A Mitchell - Best Practice & Research Clinical Haematology, 2015 - Elsevier
Dismal outcomes of acute myeloid leukemia (AML), especially in the elderly, are mainly
associated with leukemia relapse and primary no response to initial therapy. This review will
focus on AML relapse, and how a better understanding of the evolutionary stages that lead
to relapse might help us improve disease outcome. The fact that the relapse rate for some
AMLs is so high indicates that we do not truly understand the biology of relapse or possibly
that we are not implementing our current understanding into, clinical practice. Therefore, this …
associated with leukemia relapse and primary no response to initial therapy. This review will
focus on AML relapse, and how a better understanding of the evolutionary stages that lead
to relapse might help us improve disease outcome. The fact that the relapse rate for some
AMLs is so high indicates that we do not truly understand the biology of relapse or possibly
that we are not implementing our current understanding into, clinical practice. Therefore, this …
