Clodronate liposomes: perspectives in research and therapeutics
N van Rooijen… - Journal of liposome …, 2002 - Taylor & Francis
N van Rooijen, E van Kesteren-Hendrikx
Journal of liposome research, 2002•Taylor & FrancisLiposomes encapsulating the bis phosphonate clodronate can be used for the transient
suppression of macrophage functions. Given the important role of macrophages in various
disorders, the application of clodronate liposomes has been studied in several models of
rheumatoid arthritis, neurological disorders such as experimental allergic encephalomyelitis
and spinal cord injury, autoantibody mediated disorders such as immune thrombocytopenic
purpura (ITP) and for the improvement of the efficacy of gene transfer and drug targeting.
suppression of macrophage functions. Given the important role of macrophages in various
disorders, the application of clodronate liposomes has been studied in several models of
rheumatoid arthritis, neurological disorders such as experimental allergic encephalomyelitis
and spinal cord injury, autoantibody mediated disorders such as immune thrombocytopenic
purpura (ITP) and for the improvement of the efficacy of gene transfer and drug targeting.
Abstract
Liposomes encapsulating the bisphosphonate clodronate can be used for the transient suppression of macrophage functions. Given the important role of macrophages in various disorders, the application of clodronate liposomes has been studied in several models of rheumatoid arthritis, neurological disorders such as experimental allergic encephalomyelitis and spinal cord injury, autoantibody mediated disorders such as immune thrombocytopenic purpura (ITP) and for the improvement of the efficacy of gene transfer and drug targeting.
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