Acquired lymphedema: an urgent need for adequate animal models
C Hadamitzky, R Pabst - Cancer research, 2008 - AACR
C Hadamitzky, R Pabst
Cancer research, 2008•AACRIn cancer patients, the removal of tumor-draining lymph nodes during tumor resection can
lead to acquired lymphedema. This disease, which is characterized by tissue swelling and
increased risk of infection due to restricted lymph flow, lacks an effective treatment.
Limitations to the design and conduct of randomized trials to date have limited the
evaluation of proposed surgical techniques. As a result, animal models have provided an
important research base. This review summarizes work in canine, rabbit, and rodent models …
lead to acquired lymphedema. This disease, which is characterized by tissue swelling and
increased risk of infection due to restricted lymph flow, lacks an effective treatment.
Limitations to the design and conduct of randomized trials to date have limited the
evaluation of proposed surgical techniques. As a result, animal models have provided an
important research base. This review summarizes work in canine, rabbit, and rodent models …
Abstract
In cancer patients, the removal of tumor-draining lymph nodes during tumor resection can lead to acquired lymphedema. This disease, which is characterized by tissue swelling and increased risk of infection due to restricted lymph flow, lacks an effective treatment. Limitations to the design and conduct of randomized trials to date have limited the evaluation of proposed surgical techniques. As a result, animal models have provided an important research base. This review summarizes work in canine, rabbit, and rodent models of acquired lymphedema, focusing on arising limitations and potential applications. [Cancer Res 2008;68(2):343–5]
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