Reversal of natural killer cell exhaustion by TIM-3 blockade
A Gallois, I Silva, I Osman, N Bhardwaj - Oncoimmunology, 2014 - Taylor & Francis
A Gallois, I Silva, I Osman, N Bhardwaj
Oncoimmunology, 2014•Taylor & FrancisNatural killer (NK) cells are innate immune cells that become progressively exhausted in
advanced stage cancer, crippling their ability to execute antitumor functions. We previously
characterized the nature of NK cell exhaustion in metastatic melanoma patients, reporting a
correlation with high expression of TIM-3. Blockade of this immune checkpoint molecule
reversed the exhausted phenotype and improved NK cell function.
advanced stage cancer, crippling their ability to execute antitumor functions. We previously
characterized the nature of NK cell exhaustion in metastatic melanoma patients, reporting a
correlation with high expression of TIM-3. Blockade of this immune checkpoint molecule
reversed the exhausted phenotype and improved NK cell function.
Natural killer (NK) cells are innate immune cells that become progressively exhausted in advanced stage cancer, crippling their ability to execute antitumor functions. We previously characterized the nature of NK cell exhaustion in metastatic melanoma patients, reporting a correlation with high expression of TIM-3. Blockade of this immune checkpoint molecule reversed the exhausted phenotype and improved NK cell function.
Taylor & Francis Online