A selective role of NKG2D in inflammatory and autoimmune diseases
The NKG2D activating receptor has been implicated in numerous autoimmune diseases. We
tested the role of NKG2D in models of autoimmunity and inflammation using NKG2D
knockout mice and antibody blockade experiments. The severity of experimental
autoimmune encephalitis (EAE) was decreased in NKG2D-deficient mice when the disease
was induced with a limiting antigen dose, but unchanged with an optimal antigen dose.
Surprisingly, however, NKG2D deficiency had no detectable effect in several other models …
tested the role of NKG2D in models of autoimmunity and inflammation using NKG2D
knockout mice and antibody blockade experiments. The severity of experimental
autoimmune encephalitis (EAE) was decreased in NKG2D-deficient mice when the disease
was induced with a limiting antigen dose, but unchanged with an optimal antigen dose.
Surprisingly, however, NKG2D deficiency had no detectable effect in several other models …