[HTML][HTML] Tumor necrosis factor-induced nonapoptotic cell death requires receptor-interacting protein-mediated cellular reactive oxygen species accumulation
The mechanism of tumor necrosis factor (TNF)-induced nonapoptotic cell death is largely
unknown, although the mechanism of TNF-induced apoptosis has been studied extensively.
In wild-type mouse embryonic fibroblast cells under a caspase-inhibited condition, TNF
effectively induced cell death that morphologically resembled necrosis. In this study, we
utilized gene knockout mouse embryonic fibroblasts cells and found that tumor necrosis
factor receptor (TNFR) I mediates TNF-induced necrotic cell death, and that RIP, FADD, and …
unknown, although the mechanism of TNF-induced apoptosis has been studied extensively.
In wild-type mouse embryonic fibroblast cells under a caspase-inhibited condition, TNF
effectively induced cell death that morphologically resembled necrosis. In this study, we
utilized gene knockout mouse embryonic fibroblasts cells and found that tumor necrosis
factor receptor (TNFR) I mediates TNF-induced necrotic cell death, and that RIP, FADD, and …