[HTML][HTML] RIPK3-mediated necroptosis promotes donor kidney inflammatory injury and reduces allograft survival

A Lau, S Wang, J Jiang, A Haig, A Pavlosky… - American Journal of …, 2013 - Elsevier
Kidney transplant injury occurs with ischemia and alloimmunity. Members of the receptor
interacting protein kinase family (RIPK1, 3) are key regulators of “necroptosis,” a newly
recognized, regulated form of necrosis. Necroptosis and apoptosis death appear to be
counterbalanced as caspase-8 inhibition can divert death from apoptosis to necrosis.
Inhibition of necroptosis in donor organs to limit injury has not been studied in transplant
models. In this study, necroptosis was triggered in caspase inhibited tubular epithelial cells …