Use of serogroup B meningococcal vaccines in adolescents and young adults: recommendations of the Advisory Committee on Immunization Practices, 2015

JR MacNeil, L Rubin, T Folaranmi… - Morbidity and Mortality …, 2015 - JSTOR
JR MacNeil, L Rubin, T Folaranmi, IR Ortega-Sanchez, M Patel, SW Martin
Morbidity and Mortality Weekly Report, 2015JSTOR
Methods The ACIP Meningococcal Vaccines Work Group reviewed the immunogenicity and
safety data from seven clinical trials of MenB-FHbp (2–5)(Pfizer, unpublished data) and five
clinical trials of MenB-4C (6–10) during monthly telecon ferences. The work group evaluated
the available published and unpublished data and evidence regarding meningococcal
disease epidemiology in the United States, carriage, costeffectiveness, immunogenicity, and
safety. Based on a literature search and consultation with the manufacturers, these studies …
Methods
The ACIP Meningococcal Vaccines Work Group reviewed the immunogenicity and safety data from seven clinical trials of MenB-FHbp (2–5)(Pfizer, unpublished data) and five clinical trials of MenB-4C (6–10) during monthly telecon ferences. The work group evaluated the available published and unpublished data and evidence regarding meningococcal disease epidemiology in the United States, carriage, costeffectiveness, immunogenicity, and safety. Based on a literature search and consultation with the manufacturers, these studies represent all known clinical trials and evidence for these two vaccines. A summary of the data reviewed and Work Group discussions was presented to ACIP, and recommendations for use of MenB vaccines in adolescents and young adults were approved by ACIP at its June 24, 2015, meeting (meeting minutes are available at http://www. cdc. gov/vaccines/acip/meetings/meetings-info. html). The type and quality of evidence supporting the use of MenB vaccines in adolescents and young adults, including college stu dents, was evaluated using the Grading of Recommendations, Assessment, Development, and Evaluation (GRADE) frame work (11, 12)(Table 1).
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