A human isolate of Nipah virus from an outbreak of febrile encephalitis in Malaysia that
coincided with a field outbreak of disease in pigs was used to infect eight 6-week-old pigs
orally or subcutaneously and two cats oronasally. In pigs, the virus induced a respiratory and
neurological syndrome consistent with that observed in the Malaysian pigs. Not all the pigs
showed clinical signs, but Nipah virus was recovered from the nose and oropharynx of both
clinically and sub-clinically infected animals. Natural infection of in-contact pigs, which was …