Multiple roles of the cell cycle inhibitor p21CDKN1A in the DNA damage response
Among cell cycle regulatory proteins that are activated following DNA damage, the cyclin-
dependent kinase inhibitor p21CDKN1A plays essential roles in the DNA damage response,
by inducing cell cycle arrest, direct inhibition of DNA replication, as well as by regulating
fundamental processes, like apoptosis and transcription. These functions are performed
through the ability of p21 to interact with a number of proteins involved in these processes.
Despite an initial controversy, during the last years several lines of evidence have also …
dependent kinase inhibitor p21CDKN1A plays essential roles in the DNA damage response,
by inducing cell cycle arrest, direct inhibition of DNA replication, as well as by regulating
fundamental processes, like apoptosis and transcription. These functions are performed
through the ability of p21 to interact with a number of proteins involved in these processes.
Despite an initial controversy, during the last years several lines of evidence have also …
