Activating transcription factor 6α (ATF6α) regulates airway hyperreactivity, smooth muscle proliferation, and contractility
H Unno, M Miller, P Rosenthal, A Beppu… - Journal of Allergy and …, 2018 - jacionline.org
As our studies demonstrated that ATF6a 2/2 mice had reduced levels of HDM-induced ASM
and AHR without reduced levels of airway inflammation, we examined whether an intrinsic
effect of ATF6a in mouse ASM (mASM) cells could influence ASM contraction, proliferation,
or apoptosis in vitro. These studies demonstrated that mASM cells from both WT and ATF6a
2/2 mice had similar low levels of spontaneous contraction as assessed in an ASM collagen
gel contraction assay (Fig 2, A). Incubation of WT ASM cells with either Mch (Fig 2, A) or …
and AHR without reduced levels of airway inflammation, we examined whether an intrinsic
effect of ATF6a in mouse ASM (mASM) cells could influence ASM contraction, proliferation,
or apoptosis in vitro. These studies demonstrated that mASM cells from both WT and ATF6a
2/2 mice had similar low levels of spontaneous contraction as assessed in an ASM collagen
gel contraction assay (Fig 2, A). Incubation of WT ASM cells with either Mch (Fig 2, A) or …
