[PDF][PDF] A novel protective role for FXR against inflammasome activation and endotoxemia
O Garcia-Irigoyen, A Moschetta - Cell metabolism, 2017 - cell.com
O Garcia-Irigoyen, A Moschetta
Cell metabolism, 2017•cell.comDuring conditions of impaired bile flow (cholestasis), increased serum bile acids (BAs) are
prognostic markers of sepsis. In this issue, Hao et al.(2017) show that the BA receptor FXR
binds NLRP3 inflammasome in macrophages and inhibits activation of inflammasome
components, thus reducing endotoxemia in cholestasis.
prognostic markers of sepsis. In this issue, Hao et al.(2017) show that the BA receptor FXR
binds NLRP3 inflammasome in macrophages and inhibits activation of inflammasome
components, thus reducing endotoxemia in cholestasis.
During conditions of impaired bile flow (cholestasis), increased serum bile acids (BAs) are prognostic markers of sepsis. In this issue, Hao et al. (2017) show that the BA receptor FXR binds NLRP3 inflammasome in macrophages and inhibits activation of inflammasome components, thus reducing endotoxemia in cholestasis.
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