Modulating bile acid pathways and TGR5 receptors for treating liver and GI diseases
H Malhi, M Camilleri - Current opinion in pharmacology, 2017 - Elsevier
Highlights•Bile acids are central signals in enterohepatic communication.•The natural
receptors for bile acids [farnesoid X receptor and G protein-coupled bile acid receptor 1
(GPBAR1) also known as TGR5] and transporters are therapeutic targets.•Obeticholic acid
(a selective FXR agonist) and NGM282 (a non-mitogenic FGF-19 analog) are two of the
agents in this pipeline.Bile acids are central signals in enterohepatic communication and
also integrate microbiota-derived signals into this signaling axis. Discovery of the tissue …
receptors for bile acids [farnesoid X receptor and G protein-coupled bile acid receptor 1
(GPBAR1) also known as TGR5] and transporters are therapeutic targets.•Obeticholic acid
(a selective FXR agonist) and NGM282 (a non-mitogenic FGF-19 analog) are two of the
agents in this pipeline.Bile acids are central signals in enterohepatic communication and
also integrate microbiota-derived signals into this signaling axis. Discovery of the tissue …