[HTML][HTML] Topogenesis and homeostasis of fatty acyl-CoA reductase 1
M Honsho, S Asaoku, K Fukumoto, Y Fujiki - Journal of Biological Chemistry, 2013 - ASBMB
Peroxisomal fatty acyl-CoA reductase 1 (Far1) is essential for supplying fatty alcohols
required for ether bond formation in ether glycerophospholipid synthesis. The stability of
Far1 is regulated by a mechanism that is dependent on cellular plasmalogen levels.
However, the membrane topology of Far1 and how Far1 is targeted to membranes remain
largely unknown. Here, Far1 is shown to be a peroxisomal tail-anchored protein. The
hydrophobic C terminus of Far1 binds to Pex19p, a cytosolic receptor harboring a C-terminal …
required for ether bond formation in ether glycerophospholipid synthesis. The stability of
Far1 is regulated by a mechanism that is dependent on cellular plasmalogen levels.
However, the membrane topology of Far1 and how Far1 is targeted to membranes remain
largely unknown. Here, Far1 is shown to be a peroxisomal tail-anchored protein. The
hydrophobic C terminus of Far1 binds to Pex19p, a cytosolic receptor harboring a C-terminal …