Rapid rebound of a preexisting CXCR4-tropic human immunodeficiency virus variant after allogeneic transplantation with CCR5 Δ32 homozygous stem cells
J Verheyen, A Thielen, N Lübke, M Dirks… - Clinical Infectious …, 2019 - academic.oup.com
J Verheyen, A Thielen, N Lübke, M Dirks, M Widera, U Dittmer, L Kordelas, M Däumer…
Clinical Infectious Diseases, 2019•academic.oup.comAllogeneic stem cell transplantation (alloSCT) of homozygous CCR5 Δ32 stem cells once
resulted in the cure of human immunodeficiency virus (HIV) infection. We have recently
reported a viral breakthrough in a similar setting. Here, we demonstrate that the rapid
rebound after alloSCT was related to a highly replicative CXCR4-tropic HIV variant, which
could already be detected before alloSCT.
resulted in the cure of human immunodeficiency virus (HIV) infection. We have recently
reported a viral breakthrough in a similar setting. Here, we demonstrate that the rapid
rebound after alloSCT was related to a highly replicative CXCR4-tropic HIV variant, which
could already be detected before alloSCT.
Abstract
Allogeneic stem cell transplantation (alloSCT) of homozygous CCR5 Δ32 stem cells once resulted in the cure of human immunodeficiency virus (HIV) infection. We have recently reported a viral breakthrough in a similar setting. Here, we demonstrate that the rapid rebound after alloSCT was related to a highly replicative CXCR4-tropic HIV variant, which could already be detected before alloSCT.
Oxford University Press