[HTML][HTML] Long-Term Control of HIV by CCR5 Delta32/Delta32 Stem-Cell Transplantation

G Hütter, D Nowak, M Mossner… - … England Journal of …, 2009 - Mass Medical Soc
G Hütter, D Nowak, M Mossner, S Ganepola, A Müßig, K Allers, T Schneider, J Hofmann…
New England Journal of Medicine, 2009Mass Medical Soc
Infection with the human immunodeficiency virus type 1 (HIV-1) requires the presence of a
CD4 receptor and a chemokine receptor, principally chemokine receptor 5 (CCR5).
Homozygosity for a 32-bp deletion in the CCR5 allele provides resistance against HIV-1
acquisition. We transplanted stem cells from a donor who was homozygous for CCR5
delta32 in a patient with acute myeloid leukemia and HIV-1 infection. The patient remained
without viral rebound 20 months after transplantation and discontinuation of antiretroviral …
Infection with the human immunodeficiency virus type 1 (HIV-1) requires the presence of a CD4 receptor and a chemokine receptor, principally chemokine receptor 5 (CCR5). Homozygosity for a 32-bp deletion in the CCR5 allele provides resistance against HIV-1 acquisition. We transplanted stem cells from a donor who was homozygous for CCR5 delta32 in a patient with acute myeloid leukemia and HIV-1 infection. The patient remained without viral rebound 20 months after transplantation and discontinuation of antiretroviral therapy. This outcome demonstrates the critical role CCR5 plays in maintaining HIV-1 infection.
The New England Journal Of Medicine