[HTML][HTML] Characterization of a brain-enriched chaperone, MRJ, that inhibits Huntingtin aggregation and toxicity independently
JZ Chuang, H Zhou, M Zhu, SH Li, XJ Li… - Journal of Biological …, 2002 - ASBMB
Molecular chaperones are involved in a wide range of cellular events, such as protein
folding and oligomeric protein complex assembly. DnaK-and DnaJ-like proteins are the two
major classes of molecular chaperones in mammals. Recent studies have shown that DnaJ-
like family proteins can inhibit polyglutamine aggregation, a hallmark of many
neurodegenerative diseases, including Huntington's disease (HD). Although most DnaJ-like
proteins studied are ubiquitously expressed, some have restricted expression, so it is …
folding and oligomeric protein complex assembly. DnaK-and DnaJ-like proteins are the two
major classes of molecular chaperones in mammals. Recent studies have shown that DnaJ-
like family proteins can inhibit polyglutamine aggregation, a hallmark of many
neurodegenerative diseases, including Huntington's disease (HD). Although most DnaJ-like
proteins studied are ubiquitously expressed, some have restricted expression, so it is …