Brown adipose tissue: updates in cellular and molecular biology
TCL Bargut, MB Aguila, CA Mandarim-de-Lacerda - Tissue and Cell, 2016 - Elsevier
Brown adipose tissue (BAT) is mainly composed of adipocytes, it is highly vascularized and
innervated, and can be activated in adult humans. Brown adipocytes are responsible for
performing non-shivering thermogenesis, which is exclusively mediated by uncoupling
protein (UCP)-1 (a protein found in the inner mitochondrial membrane), the hallmark of BAT,
responsible for the uncoupling of the proton leakage from the ATP production, therefore,
generating heat (ie thermogenesis). Besides UCP1, other compounds are essential not only …
innervated, and can be activated in adult humans. Brown adipocytes are responsible for
performing non-shivering thermogenesis, which is exclusively mediated by uncoupling
protein (UCP)-1 (a protein found in the inner mitochondrial membrane), the hallmark of BAT,
responsible for the uncoupling of the proton leakage from the ATP production, therefore,
generating heat (ie thermogenesis). Besides UCP1, other compounds are essential not only …