Bioenergetic profile experiment using C2C12 myoblast cells

DG Nicholls, VM Darley-Usmar, M Wu… - JoVE (Journal of …, 2010 - jove.com
The ability to measure cellular metabolism and understand mitochondrial dysfunction, has
enabled scientists worldwide to advance their research in understanding the role of
mitochondrial function in obesity, diabetes, aging, cancer, cardiovascular function and safety
toxicity. Cellular metabolism is the process of substrate uptake, such as oxygen, glucose,
fatty acids, and glutamine, and subsequent energy conversion through a series of
enzymatically controlled oxidation and reduction reactions. These intracellular biochemical …