Complex assemblies of factors IX and X regulate the initiation, maintenance, and shutdown of blood coagulation
T Zögg, H Brandstetter - Progress in Molecular Biology and Translational …, 2011 - Elsevier
Blood hemostasis is accomplished by a complex network of (anti-) coagulatory and
fibrinolytic processes. These physiological processes are implemented by the assembly of
multiprotein complexes involving both humoral and cellular components. Coagulation factor
X, and particularly, factor IX, exemplify the dramatic enhancement that is obtained by the
synergistic interaction of cell surface, inorganic and protein cofactors, protease, and
substrate. With a focus on structure–function relationship, we review the current knowledge …
fibrinolytic processes. These physiological processes are implemented by the assembly of
multiprotein complexes involving both humoral and cellular components. Coagulation factor
X, and particularly, factor IX, exemplify the dramatic enhancement that is obtained by the
synergistic interaction of cell surface, inorganic and protein cofactors, protease, and
substrate. With a focus on structure–function relationship, we review the current knowledge …