RNAi-mediated ADAM9 gene silencing inhibits metastasis of adenoid cystic carcinoma cells
Q Xu, X Liu, Y Cai, Y Yu, W Chen - Tumor Biology, 2010 - Springer
Q Xu, X Liu, Y Cai, Y Yu, W Chen
Tumor Biology, 2010•SpringerA disintegrin and metalloproteinase 9 (ADAM9) is a type I transmembrane protein that has
been associated with cancer development and metastases. Here, we show that ADAM9 is
highly expressed in metastatic cancer tissues and in an adenoid cystic carcinoma cell line
with a high metastatic potential. Using RNA interference for gene silencing, we show that
ADAM9 is essential for in vitro cancer cell proliferation and invasion as well as in vivo cancer
metastasis in an experimental murine model of lung metastases. These data indicate that …
been associated with cancer development and metastases. Here, we show that ADAM9 is
highly expressed in metastatic cancer tissues and in an adenoid cystic carcinoma cell line
with a high metastatic potential. Using RNA interference for gene silencing, we show that
ADAM9 is essential for in vitro cancer cell proliferation and invasion as well as in vivo cancer
metastasis in an experimental murine model of lung metastases. These data indicate that …
Abstract
A disintegrin and metalloproteinase 9 (ADAM9) is a type I transmembrane protein that has been associated with cancer development and metastases. Here, we show that ADAM9 is highly expressed in metastatic cancer tissues and in an adenoid cystic carcinoma cell line with a high metastatic potential. Using RNA interference for gene silencing, we show that ADAM9 is essential for in vitro cancer cell proliferation and invasion as well as in vivo cancer metastasis in an experimental murine model of lung metastases. These data indicate that ADAM9 is potentially an important new therapeutic target for the prevention of tumor metastases in adenoid cystic carcinoma.
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