[HTML][HTML] Role of ADAM-9 disintegrin-cysteine-rich domains in human keratinocyte migration
P Zigrino, J Steiger, JW Fox, S Loffek, A Schild… - Journal of Biological …, 2007 - ASBMB
ADAM-9 belongs to a family of transmembrane, disintegrin-containing metalloproteinases
involved in protein ectodomain shedding and cell-cell and cell-matrix interactions. The aim
of this study was to analyze the expression of ADAM-9 in skin and to assess the role of this
proteolytic/adhesive protein in skin physiology. In normal skin, ADAM-9 expression was
detected in both the epidermis and dermis and in vitro in keratinocytes and fibroblasts. Here
we report that ADAM-9 functions as a cell adhesion molecule via its disintegrin-cysteine-rich …
involved in protein ectodomain shedding and cell-cell and cell-matrix interactions. The aim
of this study was to analyze the expression of ADAM-9 in skin and to assess the role of this
proteolytic/adhesive protein in skin physiology. In normal skin, ADAM-9 expression was
detected in both the epidermis and dermis and in vitro in keratinocytes and fibroblasts. Here
we report that ADAM-9 functions as a cell adhesion molecule via its disintegrin-cysteine-rich …
