[HTML][HTML] Pulmonary CD103+ dendritic cells prime Th2 responses to inhaled allergens
H Nakano, ME Free, GS Whitehead, S Maruoka… - Mucosal …, 2012 - Elsevier
Allergic asthma stems largely from the actions of T helper 2 (Th2) cells, but the pathways that
initiate Th2 responses to inhaled allergens are not fully understood. In the lung, there are
two major subsets of dendritic cells (DCs), displaying CD11b or CD103. We found that after
taking up inhaled ovalbumin in vivo, purified CD103+ DCs from the lung or lung-draining
lymph nodes primed Th2 differentiation ex vivo. Th2 induction by CD103+ DCs was also
seen when cockroach or house dust mite allergens were used. In contrast, CD11b hi DCs …
initiate Th2 responses to inhaled allergens are not fully understood. In the lung, there are
two major subsets of dendritic cells (DCs), displaying CD11b or CD103. We found that after
taking up inhaled ovalbumin in vivo, purified CD103+ DCs from the lung or lung-draining
lymph nodes primed Th2 differentiation ex vivo. Th2 induction by CD103+ DCs was also
seen when cockroach or house dust mite allergens were used. In contrast, CD11b hi DCs …