Oxysterols: From cholesterol metabolites to key mediators

V Mutemberezi, O Guillemot-Legris… - Progress in lipid research, 2016 - Elsevier
Oxysterols are cholesterol metabolites that can be produced through enzymatic or radical
processes. They constitute a large family of lipids (ie the oxysterome) involved in a plethora
of physiological processes. They can act through GPCR (eg EBI2, SMO, CXCR2), nuclear
receptors (LXR, ROR, ERα) and through transporters or regulatory proteins. Their
physiological effects encompass cholesterol, lipid and glucose homeostasis. Additionally,
they were shown to be involved in other processes such as immune regulatory functions and …