[HTML][HTML] Ursolic acid suppresses interleukin-17 (IL-17) production by selectively antagonizing the function of RORγt protein
Th17 cells have recently emerged as a major player in inflammatory and autoimmune
diseases via the production of pro-inflammatory cytokines IL-17, IL-17F, and IL-22. The
differentiation of Th17 cells and the associated cytokine production is directly controlled by
RORγt. Here we show that ursolic acid (UA), a small molecule present in herbal medicine,
selectively and effectively inhibits the function of RORγt, resulting in greatly decreased IL-17
expression in both developing and differentiated Th17 cells. In addition, treatment with UA …
diseases via the production of pro-inflammatory cytokines IL-17, IL-17F, and IL-22. The
differentiation of Th17 cells and the associated cytokine production is directly controlled by
RORγt. Here we show that ursolic acid (UA), a small molecule present in herbal medicine,
selectively and effectively inhibits the function of RORγt, resulting in greatly decreased IL-17
expression in both developing and differentiated Th17 cells. In addition, treatment with UA …