Sputum neutrophil counts are associated with more severe asthma phenotypes using cluster analysis
WC Moore, AT Hastie, X Li, H Li, WW Busse… - Journal of Allergy and …, 2014 - Elsevier
Background Clinical cluster analysis from the Severe Asthma Research Program (SARP)
identified 5 asthma subphenotypes that represent the severity spectrum of early-onset
allergic asthma, late-onset severe asthma, and severe asthma with chronic obstructive
pulmonary disease characteristics. Analysis of induced sputum from a subset of SARP
subjects showed 4 sputum inflammatory cellular patterns. Subjects with concurrent
increases in eosinophil (≥ 2%) and neutrophil (≥ 40%) percentages had characteristics of …
identified 5 asthma subphenotypes that represent the severity spectrum of early-onset
allergic asthma, late-onset severe asthma, and severe asthma with chronic obstructive
pulmonary disease characteristics. Analysis of induced sputum from a subset of SARP
subjects showed 4 sputum inflammatory cellular patterns. Subjects with concurrent
increases in eosinophil (≥ 2%) and neutrophil (≥ 40%) percentages had characteristics of …