Apoptosis signaling in influenza virus propagation, innate host defense, and lung injury

S Herold, S Ludwig, S Pleschka… - Journal of leukocyte …, 2012 - academic.oup.com
Journal of leukocyte biology, 2012academic.oup.com
A review of mechanisms of apoptosis induction in influenza virus-infected cells, and the
impact of apoptotic signaling on viral propagation, immune responses, and tissue injury.
Programmed cell death is a crucial cellular response frequently observed in IV-infected
tissue. This article reviews the current knowledge on the molecular virus–host interactions
that induce apoptosis pathways in an IV-infected cell and the functional implications of these
cellular signaling events on viral propagation at distinct steps during the viral replication …
Abstract
A review of mechanisms of apoptosis induction in influenza virus-infected cells, and the impact of apoptotic signaling on viral propagation, immune responses, and tissue injury.
Programmed cell death is a crucial cellular response frequently observed in IV-infected tissue. This article reviews the current knowledge on the molecular virus–host interactions that induce apoptosis pathways in an IV-infected cell and the functional implications of these cellular signaling events on viral propagation at distinct steps during the viral replication cycle. Furthermore, it summarizes the role of IV-induced apoptosis pathways in equilibrating the hostˈs antiviral immune response between effective viral clearance and development of severe apoptotic lung injury.
Oxford University Press