The macrophage migration inhibitory factor-glucocorticoid dyad: regulation of inflammation and immunity
H Flaster, J Bernhagen, T Calandra… - Molecular …, 2007 - academic.oup.com
Molecular Endocrinology, 2007•academic.oup.com
The cytokine macrophage migration inhibitory factor (MIF) occupies a unique position in
physiology by its ability to directly regulate the immunosuppressive actions of
glucocorticoids. We review herein the interactions between MIF and glucocorticoids within
the immune system and discuss the relevance of the MIF-glucocorticoid regulatory dyad in
physiology and immunopathology. Therapeutic antagonism of MIF may be an effective
approach for steroid-sparing therapies in patients with refractory autoimmune or …
physiology by its ability to directly regulate the immunosuppressive actions of
glucocorticoids. We review herein the interactions between MIF and glucocorticoids within
the immune system and discuss the relevance of the MIF-glucocorticoid regulatory dyad in
physiology and immunopathology. Therapeutic antagonism of MIF may be an effective
approach for steroid-sparing therapies in patients with refractory autoimmune or …
Abstract
The cytokine macrophage migration inhibitory factor (MIF) occupies a unique position in physiology by its ability to directly regulate the immunosuppressive actions of glucocorticoids. We review herein the interactions between MIF and glucocorticoids within the immune system and discuss the relevance of the MIF-glucocorticoid regulatory dyad in physiology and immunopathology. Therapeutic antagonism of MIF may be an effective approach for steroid-sparing therapies in patients with refractory autoimmune or inflammatory diseases.
Oxford University Press