The quest to understand why we age has given rise to numerous lines of investigation that
have gradually converged to include metabolic control by mitochondrial activity as a major
player. That is, the ideal balance between nutrient uptake, its transduction into usable
energy, and the mitigation of damaging byproducts can be regulated by mitochondrial
respiration and output (ATP, reactive oxygen species (ROS), and heat). Mitochondrial
inefficiency through proton leak, which uncouples substrate oxidation from ADP …