T and natural killer (NK) lymphocytes are considered the main effector players in the
immune response against tumors. Full activation of T and NK lymphocytes requires the
coordinated participation of several surface receptors that meet their cognate ligands
through structured transient cell-to-cell interactions known as immune synapses. In the case
of T cells, the main route of stimulation is driven by antigens as recognized in the form of
short polypeptides associated with major histocompatibility complex (MHC) antigen …