Novel immunotherapies for multiple myeloma
M D'Agostino, M Boccadoro, EL Smith - Current hematologic malignancy …, 2017 - Springer
M D'Agostino, M Boccadoro, EL Smith
Current hematologic malignancy reports, 2017•SpringerAbstract Purpose of Review The treatment landscape of multiple myeloma is rapidly
changing; however, despite improvement in patients' survival, it still remains a largely
incurable disease. One hallmark of myeloma is substantial immune dysfunction leading to
an increased infection rate and the inability of immune surveillance to detect neoplastic
cells. Here, we critically analyze clinical approaches to harness the immune system to
overcome this defect with a focus on antibody based and adoptive cellular therapies. Recent …
changing; however, despite improvement in patients' survival, it still remains a largely
incurable disease. One hallmark of myeloma is substantial immune dysfunction leading to
an increased infection rate and the inability of immune surveillance to detect neoplastic
cells. Here, we critically analyze clinical approaches to harness the immune system to
overcome this defect with a focus on antibody based and adoptive cellular therapies. Recent …
Purpose of Review
The treatment landscape of multiple myeloma is rapidly changing; however, despite improvement in patients’ survival, it still remains a largely incurable disease. One hallmark of myeloma is substantial immune dysfunction leading to an increased infection rate and the inability of immune surveillance to detect neoplastic cells. Here, we critically analyze clinical approaches to harness the immune system to overcome this defect with a focus on antibody based and adoptive cellular therapies.
Recent Findings
Clinical trials exploring these immunotherapies to treat myeloma are now well underway and show promising results. In relapsed myeloma, monoclonal antibodies directed against plasma cell antigens and immune checkpoints have already shown substantial efficacy. In parallel, trials of adoptive cellular therapy have exciting promise in myeloma, having induced dramatic responses in a handful of early study participants.
Summary
Taken together, immunotherapeutic approaches hold enormous potential in the field of multiple myeloma and in the near future can be combined with or even replace the current standard of care.
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