Although adjuvants are important components of vaccines, few studies have been
conducted to establish the criteria on adjuvant selection and to investigate mechanisms of
adjuvant actions during vaccination. Here we found that complete Freund adjuvant (CFA)
induced a CD11b+ cell population in a B-cell independent manner. This cell population
exhibited strong ability to inhibit T-cell− mediated rejection of tumor transplants. In vitro
studies indicated that these cells induced T-cell apoptosis and down-regulated interferon-γ …