Reprogramming the tumor microenvironment: tumor-induced immunosuppressive factors paralyze T cells
It has become evident that tumor-induced immuno-suppressive factors in the tumor
microenvironment play a major role in suppressing normal functions of effector T cells.
These factors serve as hurdles that limit the therapeutic potential of cancer
immunotherapies. This review focuses on illustrating the molecular mechanisms of
immunosuppression in the tumor microenvironment, including evasion of T-cell recognition,
interference with T-cell trafficking, metabolism, and functions, induction of resistance to T-cell …
microenvironment play a major role in suppressing normal functions of effector T cells.
These factors serve as hurdles that limit the therapeutic potential of cancer
immunotherapies. This review focuses on illustrating the molecular mechanisms of
immunosuppression in the tumor microenvironment, including evasion of T-cell recognition,
interference with T-cell trafficking, metabolism, and functions, induction of resistance to T-cell …
It has become evident that tumor-induced immuno-suppressive factors in the tumor microenvironment play a major role in suppressing normal functions of effector T cells. These factors serve as hurdles that limit the therapeutic potential of cancer immunotherapies. This review focuses on illustrating the molecular mechanisms of immunosuppression in the tumor microenvironment, including evasion of T-cell recognition, interference with T-cell trafficking, metabolism, and functions, induction of resistance to T-cell killing, and apoptosis of T cells. A better understanding of these mechanisms may help in the development of strategies to enhance the effectiveness of cancer immunotherapies.
Taylor & Francis Online