[HTML][HTML] Protection from high fat diet-induced increase in ceramide in mice lacking plasminogen activator inhibitor 1
C Shah, G Yang, I Lee, J Bielawski, YA Hannun… - Journal of Biological …, 2008 - ASBMB
Obesity increases the risk for metabolic and cardiovascular disease, and adipose tissue
plays a central role in this process. Ceramide, the key intermediate of sphingolipid
metabolism, also contributes to obesity-related disorders. We show that a high fat diet
increased ceramide levels in the adipose tissues and plasma in C57BL/6J mice via a
mechanism that involves an increase in gene expression of enzymes mediating ceramide
generation through the de novo pathway (eg serine palmitoyltransferase) and via the …
plays a central role in this process. Ceramide, the key intermediate of sphingolipid
metabolism, also contributes to obesity-related disorders. We show that a high fat diet
increased ceramide levels in the adipose tissues and plasma in C57BL/6J mice via a
mechanism that involves an increase in gene expression of enzymes mediating ceramide
generation through the de novo pathway (eg serine palmitoyltransferase) and via the …