[HTML][HTML] Myristate-derived d16: 0 sphingolipids constitute a cardiac sphingolipid pool with distinct synthetic routes and functional properties
SB Russo, R Tidhar, AH Futerman… - Journal of Biological …, 2013 - ASBMB
The enzyme serine palmitoyltransferase (SPT) catalyzes the formation of the sphingoid
base" backbone" from which all sphingolipids are derived. Previous studies have shown that
inhibition of SPT ameliorates pathological cardiac outcomes in models of lipid overload, but
the metabolites responsible for these phenotypes remain unidentified. Recent in vitro
studies have shown that incorporation of the novel subunit SPTLC3 broadens the substrate
specificity of SPT, allowing utilization of myristoyl-coenzyme A (CoA) in addition to its …
base" backbone" from which all sphingolipids are derived. Previous studies have shown that
inhibition of SPT ameliorates pathological cardiac outcomes in models of lipid overload, but
the metabolites responsible for these phenotypes remain unidentified. Recent in vitro
studies have shown that incorporation of the novel subunit SPTLC3 broadens the substrate
specificity of SPT, allowing utilization of myristoyl-coenzyme A (CoA) in addition to its …