Vitamin D binding protein: a multifunctional protein of clinical importance
MM Speeckaert, R Speeckaert, N van Geel… - Advances in clinical …, 2014 - Elsevier
Since the discovery of group-specific component and its polymorphism by Hirschfeld in
1959, research has put spotlight on this multifunctional transport protein (vitamin D binding
protein, DBP). Besides the transport of vitamin D metabolites, DBP is a plasma glycoprotein
with many important functions, including sequestration of actin, modulation of immune and
inflammatory responses, binding of fatty acids, and control of bone development. A
considerable DBP polymorphism has been described with a specific allele distribution in …
1959, research has put spotlight on this multifunctional transport protein (vitamin D binding
protein, DBP). Besides the transport of vitamin D metabolites, DBP is a plasma glycoprotein
with many important functions, including sequestration of actin, modulation of immune and
inflammatory responses, binding of fatty acids, and control of bone development. A
considerable DBP polymorphism has been described with a specific allele distribution in …