[HTML][HTML] Protein hydroxylation catalyzed by 2-oxoglutarate-dependent oxygenases
S Markolovic, SE Wilkins, CJ Schofield - Journal of Biological Chemistry, 2015 - ASBMB
The post-translational hydroxylation of prolyl and lysyl residues, as catalyzed by 2-
oxoglutarate (2OG)-dependent oxygenases, was first identified in collagen biosynthesis.
2OG oxygenases also catalyze prolyl and asparaginyl hydroxylation of the hypoxia-
inducible factors that play important roles in the adaptive response to hypoxia.
Subsequently, they have been shown to catalyze N-demethylation (via hydroxylation) of N ϵ-
methylated histone lysyl residues, as well as hydroxylation of multiple other residues …
oxoglutarate (2OG)-dependent oxygenases, was first identified in collagen biosynthesis.
2OG oxygenases also catalyze prolyl and asparaginyl hydroxylation of the hypoxia-
inducible factors that play important roles in the adaptive response to hypoxia.
Subsequently, they have been shown to catalyze N-demethylation (via hydroxylation) of N ϵ-
methylated histone lysyl residues, as well as hydroxylation of multiple other residues …