[HTML][HTML] Radiation induced secondary malignancies: a review article

CB Dracham, A Shankar, R Madan - Radiation oncology journal, 2018 - ncbi.nlm.nih.gov
CB Dracham, A Shankar, R Madan
Radiation oncology journal, 2018ncbi.nlm.nih.gov
Radiation-induced second malignancies (RISM) is one of the important late side effects of
radiation therapy and has an impact on optimal treatment decision-making. Many factors
contribute to the development of RISM such as age at radiation, dose and volume of
irradiated area, type of irradiated organ and tissue, radiation technique and individual and
family history of cancer. Exact mechanism of RISM is unknown. But nowadays, it is a
growing concern in oncology because of the increased number of cancer survivors and …
Abstract
Radiation-induced second malignancies (RISM) is one of the important late side effects of radiation therapy and has an impact on optimal treatment decision-making. Many factors contribute to the development of RISM such as age at radiation, dose and volume of irradiated area, type of irradiated organ and tissue, radiation technique and individual and family history of cancer. Exact mechanism of RISM is unknown. But nowadays, it is a growing concern in oncology because of the increased number of cancer survivors and efforts are being made to prevent or decrease the incidence of RISM. The primary search for articles was carried via Google Scholar and PubMed with keywords included ‘radiation induced malignancies, second malignancies, and chemotherapy induced malignancies’. Additional papers were found through references from relevant articles. In this review article, we have discussed about the pathogenesis, factors contributing to RISM, screening and prevention strategies of RISM.
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