Natriuretic peptides

ER Levin, DG Gardner… - New England Journal of …, 1998 - Mass Medical Soc
ER Levin, DG Gardner, WK Samson
New England Journal of Medicine, 1998Mass Medical Soc
In 1981, de Bold and his colleagues made the seminal observation that infusion of extracts
of atrial tissue into rats caused a copious natriuresis. 1 This then led to the isolation and
cloning of atrial natriuretic peptide, the first member of a family of peptides with potent
natriuretic, diuretic, and vasorelaxant activity. 2 Subsequent contributions from many
investigators have expanded our understanding of the family of natriuretic peptides, their
receptors, and their cellular actions that regulate physiologic functions. Studies using drugs …
In 1981, de Bold and his colleagues made the seminal observation that infusion of extracts of atrial tissue into rats caused a copious natriuresis.1 This then led to the isolation and cloning of atrial natriuretic peptide, the first member of a family of peptides with potent natriuretic, diuretic, and vasorelaxant activity.2 Subsequent contributions from many investigators have expanded our understanding of the family of natriuretic peptides, their receptors, and their cellular actions that regulate physiologic functions. Studies using drugs to inhibit the function of some natriuretic peptide receptors or to prevent the degradation of natriuretic peptides have confirmed the importance . . .
The New England Journal Of Medicine