Long-term acyclovir suppression of frequently recurring genital herpes simplex virus infection: a multicenter double-blind trial
GJ Mertz, CC Jones, J Mills, KH Fife, SM Lemon… - Jama, 1988 - jamanetwork.com
Normal adults with six or more episodes of genital herpes in the previous year were enrolled
in a one-year, multicenter, double-blind trial comparing placebo with 400 mg of acyclovir
administered orally twice daily. Patients with episodes during the study were offered 200 mg
of acyclovir administered orally five times daily for five days; this allowed comparison of
suppressive and episodic treatment. After one year, 227 (44%) of 519 patients receiving
suppressive treatment and seven (2%) of 431 receiving placebo (episodic) treatment …
in a one-year, multicenter, double-blind trial comparing placebo with 400 mg of acyclovir
administered orally twice daily. Patients with episodes during the study were offered 200 mg
of acyclovir administered orally five times daily for five days; this allowed comparison of
suppressive and episodic treatment. After one year, 227 (44%) of 519 patients receiving
suppressive treatment and seven (2%) of 431 receiving placebo (episodic) treatment …