[HTML][HTML] Isoform-specific regulation of insulin-dependent glucose uptake by Akt/protein kinase B
SS Bae, H Cho, J Mu, MJ Birnbaum - Journal of Biological Chemistry, 2003 - ASBMB
Recent data have implicated the serine/threonine protein kinase Akt/protein kinase B (PKB)
in a diverse array of physiological pathways, raising the question of how biological
specificity is maintained. Partial clarification derived from the observation that mice deficient
in either of the two isoforms, Akt1/PKBα or Akt2/PKBβ, demonstrate distinct abnormalities, ie
reduced organismal size or insulin resistance, respectively. However, the question still
persists as to whether these divergent phenotypes are due exclusively to tissue-specific …
in a diverse array of physiological pathways, raising the question of how biological
specificity is maintained. Partial clarification derived from the observation that mice deficient
in either of the two isoforms, Akt1/PKBα or Akt2/PKBβ, demonstrate distinct abnormalities, ie
reduced organismal size or insulin resistance, respectively. However, the question still
persists as to whether these divergent phenotypes are due exclusively to tissue-specific …