[HTML][HTML] The role of LMNA in adipose: a novel mouse model of lipodystrophy based on the Dunnigan-type familial partial lipodystrophy mutation [S]
KM Wojtanik, K Edgemon, S Viswanadha… - Journal of lipid …, 2009 - ASBMB
We investigated the role of LMNA in adipose tissue by developing a novel mouse model of
lipodystrophy. Transgenic mice were generated that express the LMNA mutation that causes
familial partial lipodystrophy of the Dunnigan type (FPLD2). The phenotype observed in
FPLD-transgenic mice resembles many of the features of human FPLD2, including lack of fat
accumulation, insulin resistance, and enlarged, fatty liver. Similar to the human disease,
FPLD-transgenic mice appear to develop normally, but after several weeks they are unable …
lipodystrophy. Transgenic mice were generated that express the LMNA mutation that causes
familial partial lipodystrophy of the Dunnigan type (FPLD2). The phenotype observed in
FPLD-transgenic mice resembles many of the features of human FPLD2, including lack of fat
accumulation, insulin resistance, and enlarged, fatty liver. Similar to the human disease,
FPLD-transgenic mice appear to develop normally, but after several weeks they are unable …