[HTML][HTML] Transcriptional regulation of FasL expression and participation of sTNF-α in response to sertoli cell injury
PL Yao, YC Lin, P Sawhney, JH Richburg - Journal of Biological Chemistry, 2007 - ASBMB
The Fas/FasL signaling pathway has previously been demonstrated to be critical for
triggering germ cell apoptosis in response to mono-(2-ethylhexyl) phthalate (MEHP)-
induced Sertoli cell injury. Although Sertoli cells ubiquitously express the FasL protein,
MEHP-induced germ cell apoptosis appears to tightly correlate with increased levels of
Sertoli cell FasL. Here we characterize the transcriptional regulation of the murine FasL
gene in Sertoli cells after MEHP exposure. A serial deletion strategy for 1.5 kb of the 5 …
triggering germ cell apoptosis in response to mono-(2-ethylhexyl) phthalate (MEHP)-
induced Sertoli cell injury. Although Sertoli cells ubiquitously express the FasL protein,
MEHP-induced germ cell apoptosis appears to tightly correlate with increased levels of
Sertoli cell FasL. Here we characterize the transcriptional regulation of the murine FasL
gene in Sertoli cells after MEHP exposure. A serial deletion strategy for 1.5 kb of the 5 …