[HTML][HTML] The protein synthesis inhibitor blasticidin s enters mammalian cells via leucine-rich repeat-containing protein 8D
CC Lee, E Freinkman, DM Sabatini… - Journal of Biological …, 2014 - ASBMB
Leucine-rich repeat-containing 8 (LRRC8) proteins have been identified as putative
receptors involved in lymphocyte development and adipocyte differentiation. They remain
poorly characterized, and no specific function has been assigned to them. There is no
consensus on how this family of proteins might function because homology searches
suggest that members of the LRRC8 family act not as plasma membrane receptors, but
rather as channels that mediate cell-cell signaling. Here we provide experimental evidence …
receptors involved in lymphocyte development and adipocyte differentiation. They remain
poorly characterized, and no specific function has been assigned to them. There is no
consensus on how this family of proteins might function because homology searches
suggest that members of the LRRC8 family act not as plasma membrane receptors, but
rather as channels that mediate cell-cell signaling. Here we provide experimental evidence …