[HTML][HTML] Opposite translational control of GLUT1 and GLUT4 glucose transporter mRNAs in response to insulin: role of mammalian target of rapamycin, protein kinase …
C Taha, Z Liu, J Jin, H Al-Hasani, N Sonenberg… - Journal of Biological …, 1999 - ASBMB
Prolonged exposure of 3T3-L1 adipocytes to insulin increases GLUT1 protein content while
diminishing GLUT4. These changes arise in part from changes in mRNA transcription. Here
we examined whether there are also specific effects of insulin on GLUT1 and GLUT4 mRNA
translation. Insulin enhanced association of GLUT1 mRNA with polyribosomes and
decreased association with monosomes, suggesting increased translation. Conversely,
insulin arrested the majority of GLUT4 transcripts in monosomes. Insulin inactivates the …
diminishing GLUT4. These changes arise in part from changes in mRNA transcription. Here
we examined whether there are also specific effects of insulin on GLUT1 and GLUT4 mRNA
translation. Insulin enhanced association of GLUT1 mRNA with polyribosomes and
decreased association with monosomes, suggesting increased translation. Conversely,
insulin arrested the majority of GLUT4 transcripts in monosomes. Insulin inactivates the …