[HTML][HTML] Diminished autophagy limits cardiac injury in mouse models of type 1 diabetes
X Xu, S Kobayashi, K Chen, D Timm, P Volden… - Journal of Biological …, 2013 - ASBMB
Cardiac autophagy is inhibited in type 1 diabetes. However, it remains unknown if the
reduced autophagy contributes to the pathogenesis of diabetic cardiomyopathy. We
addressed this question using mouse models with gain-and loss-of-autophagy. Autophagic
flux was inhibited in diabetic hearts when measured at multiple time points after diabetes
induction by streptozotocin as assessed by protein levels of microtubule-associated protein
light chain 3 form 2 (LC3-II) or GFP-LC3 puncta in the absence and presence of the …
reduced autophagy contributes to the pathogenesis of diabetic cardiomyopathy. We
addressed this question using mouse models with gain-and loss-of-autophagy. Autophagic
flux was inhibited in diabetic hearts when measured at multiple time points after diabetes
induction by streptozotocin as assessed by protein levels of microtubule-associated protein
light chain 3 form 2 (LC3-II) or GFP-LC3 puncta in the absence and presence of the …