[HTML][HTML] B-cell receptor activation induces BIC/miR-155 expression through a conserved AP-1 element
Q Yin, X Wang, J McBride, C Fewell… - Journal of Biological …, 2008 - ASBMB
microRNA-155 is an oncogenic microRNA that has been shown to be critical for B-cell
maturation and immunoglobulin production in response to antigen. In line with its function in
B-cell activation, miR-155, and its primary transcript, B-cell integration cluster (BIC), is
induced by B-cell receptor (BCR) cross-linking. Using pharmacological inhibitors in the
human B-cell line, Ramos, we show that activation of BIC and miR-155 expression by BCR
signaling occurs through the extracellular signaling-regulated kinase (ERK) and c-Jun N …
maturation and immunoglobulin production in response to antigen. In line with its function in
B-cell activation, miR-155, and its primary transcript, B-cell integration cluster (BIC), is
induced by B-cell receptor (BCR) cross-linking. Using pharmacological inhibitors in the
human B-cell line, Ramos, we show that activation of BIC and miR-155 expression by BCR
signaling occurs through the extracellular signaling-regulated kinase (ERK) and c-Jun N …