[HTML][HTML] Regulator of G protein signaling 6 (RGS6) protein ensures coordination of motor movement by modulating GABAB receptor signaling
γ-Aminobutyric acid (GABA) release from inhibitory interneurons located within the
cerebellar cortex limits the extent of neuronal excitation in part through activation of
metabotropic GABA B receptors. Stimulation of these receptors triggers a number of
downstream signaling events, including activation of GIRK channels by the Gβγ dimer
resulting in membrane hyperpolarization and inhibition of neurotransmitter release from
presynaptic sites. Here, we identify RGS6, a member of the R7 subfamily of RGS proteins, as …
cerebellar cortex limits the extent of neuronal excitation in part through activation of
metabotropic GABA B receptors. Stimulation of these receptors triggers a number of
downstream signaling events, including activation of GIRK channels by the Gβγ dimer
resulting in membrane hyperpolarization and inhibition of neurotransmitter release from
presynaptic sites. Here, we identify RGS6, a member of the R7 subfamily of RGS proteins, as …